The post-apocalyptic setting of Pokémon Pokopia is the Kanto region.
Pokopia presents Kanto in a radically different condition from the region seen in the earliest Pokémon games. Humans have abandoned the world, and the environment has become uninhabitable for many Pokémon. The player’s task is to help restore habitats and make the landscape suitable for Pokémon life again.
This setting can be easy to mix up with other Pokémon regions because Pokopia includes species from many generations, not only Pokémon originally associated with Kanto. The plot’s environmental mystery is also broader than a normal regional journey: Ditto and Professor Tangrowth investigate what happened to both humans and Pokémon. Thus, Kanto identifies the game’s setting, while the game’s roster and story reach across the wider Pokémon universe.