Which Beyoncé song features rapper Jay-Z and opens with a prominent horn sample?

Beyoncé’s song featuring Jay-Z and opening with a prominent horn sample is “Crazy in Love.”

Released in 2003, the song served as the lead single from Beyoncé’s debut solo album, Dangerously in Love. Its production was led by Rich Harrison, who built the distinctive brass hook from a sample of “Are You My Woman (Tell Me So)” by the Chi-Lites.

Jay-Z contributes a rap verse, while Beyoncé delivers the main vocal and the repeated “uh-oh” refrain. The combination of soul sampling, hip-hop, and contemporary R&B helped make the track an immediate crossover hit.

“Crazy in Love” topped the Billboard Hot 100 and won Grammy Awards for Best R&B Song and Best Rap/Sung Collaboration. It is often cited as one of the defining singles of Beyoncé’s early solo career, and its video was directed by Jake Nava.