What is the name of the Powerpuff Girls villain who disguises herself as a beautiful woman?

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Sedusa is the Powerpuff Girls villain who disguises herself as a beautiful woman.

Sedusa is a shape-shifting criminal who uses an attractive human appearance to deceive people. Her design and name evoke the mythological figure Medusa, although the character functions within the show as a modern supervillain rather than a direct retelling of the myth.

She is particularly associated with manipulation and disguise. In her stories, Sedusa attempts to exploit trust and gain access to the girls’ home or family life, creating conflicts that differ from Mojo Jojo’s science-based schemes or Fuzzy Lumpkins’ territorial outbursts.

Sedusa is a recurring but less frequent villain than the franchise’s most famous antagonists. Her distinctive identity makes her easy to distinguish from Princess Morebucks, a wealthy child who wants to become a Powerpuff Girl.

Source: Wikipedia · fact-checked Sept. 2026

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