The original The Powerpuff Girls series produced 78 episodes.
That total covers the six-season Cartoon Network series that originally ran from 1998 to 2005. Many broadcasts paired two shorter story segments within one half-hour time slot, which can make episode counts appear different depending on whether a source counts broadcast packages or individual segments.
The 78-episode figure belongs to the original animated production and should not be combined with the 2016 reboot or later specials. The show’s catalog includes stories featuring major characters such as Mojo Jojo, HIM, Fuzzy Lumpkins, and the Gangreen Gang.
This distinction between episodes and segments is a common source of confusion in listings for animated television programs.