The Powerpuff Girls protect the fictional city of Townsville in the original television series.
Townsville is the girls’ home city and the setting for most of their adventures. Blossom, Bubbles, and Buttercup regularly respond to emergencies there, including attacks by monsters, villains, and other threats.
The city’s mayor frequently contacts the girls through the hotline at Professor Utonium’s home. Although the show presents Townsville as a modern urban community, its exact location is fictional and is not tied to a real country or state.
Townsville is easy to mix up with other cartoon cities, such as Springfield from The Simpsons or Bedrock from The Flintstones. In The Powerpuff Girls, however, the city’s name is consistently Townsville.