In the 2010 film Percy Jackson & the Olympians: The Lightning Thief, Uma Thurman played Medusa.
The film is a fantasy adventure based on Rick Riordan’s 2005 novel The Lightning Thief. Directed by Chris Columbus, it follows Percy Jackson, a teenager who discovers that he is the son of the Greek god Poseidon. During the story, Percy and his friends encounter Medusa in a garden attraction modeled on the mythological monster.
Thurman’s appearance connects the modern film to the ancient Greek tradition in which Medusa is the only mortal Gorgon. The movie adapts several mythological figures and objects, but it changes details from both classical myths and Riordan’s novel for its contemporary setting.
This casting fact is sometimes confused with other screen versions of Medusa. Uma Thurman played the character in this 2010 feature film; she is not the actress who portrayed Medusa in later television adaptations or unrelated mythological productions.