In House, M.D., what is the name of House's best friend and oncology specialist?

James Wilson is House’s best friend and the oncology specialist in House, M.D.

Wilson works at Princeton-Plainsboro Teaching Hospital and frequently acts as House’s emotional counterweight. He is compassionate, socially skilled, and attentive to patients, while House is more confrontational and focused on solving the diagnostic puzzle. Their friendship remains central throughout the series.

The character is played by Robert Sean Leonard, who became closely associated with the role. Wilson’s oncology specialty also gives the show a recurring way to explore terminal illness, difficult treatment decisions, and the difference between extending life and preserving quality of life.

Wilson is not the same character as Dr. James Cameron, another member of House’s early diagnostic team. Cameron is played by Jennifer Morrison. Wilson’s first name is James, while Leonard’s real first name is Robert; this sometimes causes confusion when viewers remember the character through the actor.