What street address does House's apartment have in House M.D.?

House's apartment in House M.D. is located at 221B Baker Street.

The address is a direct reference to 221B Baker Street, the fictional London home of Sherlock Holmes. Gregory House is deliberately modeled in part on Holmes, so the apartment number functions as an easily recognizable clue to the character's literary inspiration.

House's apartment is in Princeton, New Jersey, despite the famous London address. The show uses the number as an homage rather than suggesting that House lives in England. His apartment is often used for scenes involving Wilson, House's team, private medical reasoning, and the consequences of House's drug use.

Other Holmes parallels include the names House and Holmes, the investigative use of deduction, House's musical ability, and Wilson's role as a loyal companion analogous to Dr. Watson. The address is therefore more than a location detail: it signals how the series reworks detective fiction inside a medical drama.