The saint who is the patron of musicians and is often depicted playing a harp or organ is Cecilia of Rome.
Cecilia was a Christian virgin and martyr associated with Rome, traditionally dated to the late second or early third century. According to her legend, she sang to God in her heart during her wedding celebrations, a detail that helped connect her with music and musicians.
Artists commonly show her with an organ, harp, viola, or other instruments. The organ became especially prominent in Western art, although the association may partly reflect a mistranslation or reinterpretation of the Latin wording in the Acts of Saint Cecilia rather than evidence that she personally played the instrument.
Her feast day is 22 November, and her name appears in the Roman Canon of the Mass. She is venerated in Catholic and Eastern Orthodox traditions, while the Accademia Nazionale di Santa Cecilia in Rome—founded in 1585—illustrates the lasting importance of her musical patronage.