The Netflix animated series set in the League of Legends universe is Arcane.
Arcane, also presented onscreen as Arcane: League of Legends, is an animated action-adventure series created by Christian Linke and Alex Yee. It was produced by Riot Games with French animation studio Fortiche and distributed internationally by Netflix. The series was announced during League of Legends’ tenth-anniversary celebration in 2019 and premiered in November 2021.
Its story centers on sisters Vi and Powder, later known as Jinx, amid the conflict between Piltover and Zaun. Piltover is a wealthy, technologically advanced city, while Zaun is its oppressed underground counterpart. The show expands the game’s world through character-driven drama, political conflict, and magical technology known as hextech.
Arcane is not an adaptation of one League match or a simple retelling of the game’s backstory. It uses established champions and locations while presenting a cinematic interpretation of their relationships and histories. The second season, released in 2024, was announced as the series’ final season. Other choices in the question are unrelated animated series, including Dota: Dragon’s Blood and Castlevania.