Cleopatra appears as an important ally of Bayek in Assassin's Creed Origins.
Origins is set in Ptolemaic Egypt during the political struggle involving Cleopatra, her brother Ptolemy XIII, and the Roman leader Julius Caesar. Bayek, a Medjay from Siwa, becomes involved in this conflict while pursuing members of a secretive order responsible for personal tragedy.
Cleopatra's alliance with Bayek is political as well as practical. She seeks support against her rivals and works with people who can challenge the forces controlling Egypt. The game's story uses these historical figures as part of its fictional origin story for the Hidden Ones, the organization that later becomes associated with the Assassin Brotherhood.
The game takes creative liberties with chronology and character relationships. Its main original characters, including Bayek and Aya, are fictional, while Cleopatra, Caesar, and Ptolemy XIII are historical figures. Cleopatra's presence therefore connects the game's invented Assassin mythology to documented Ptolemaic history.