Rodrigo Borgia is the Templar Grand Master and main antagonist in Assassin's Creed II.
In the game's Renaissance Italy storyline, Rodrigo operates under the title Spanish Cardinal and leads the Italian Templars. He seeks the Apple of Eden and other Pieces of Eden, believing that their power will help him control the political and religious order of Europe.
Rodrigo's historical identity is based on the real Rodrigo de Borja, who became Pope Alexander VI in 1492. The game fictionalizes his role by making him a central leader of the Templar conspiracy and by placing him in direct opposition to Ezio Auditore.
Cesare Borgia, Rodrigo's son, becomes the principal villain of Assassin's Creed Brotherhood rather than Assassin's Creed II. Lorenzo de' Medici and Girolamo Savonarola are historical figures connected to the Renaissance setting, but neither is the game's Templar Grand Master.