Which historical family leads the main Templar forces in Assassin's Creed Brotherhood?

The Borgia family leads the main Templar forces in Assassin's Creed Brotherhood.

The game's central antagonists include Rodrigo Borgia, who became Pope Alexander VI, and his son Cesare Borgia. Cesare commands the military campaign in Rome and seeks to expand Borgia power across Italy. Ezio's conflict with the family follows the events of Assassin's Creed II and drives much of Brotherhood's plot.

The Medici and Pazzi families are also important to the Renaissance setting, but they belong mainly to the political and story conflicts of Assassin's Creed II. The Sforza family appears in the broader historical background and in later series material, yet it is not the game's ruling Templar enemy. Brotherhood uses historical figures and institutions as part of its fictional Assassins-versus-Templars narrative, so the story should not be read as a literal account of Borgia history.