Which game was the first main Assassin's Creed title to feature a female protagonist option named Kassandra?

Assassin's Creed Odyssey was the first main Assassin's Creed title to feature the female protagonist option named Kassandra.

Odyssey allows the player to choose Kassandra or Alexios as the main character. Both portray the same central mercenary role and share the broad story structure, while Kassandra is the canonical protagonist in the game's wider series continuity. The adventure is set in ancient Greece during the Peloponnesian War.

Earlier main entries included important female characters and, in some cases, female playable sequences or protagonists in particular modes. Assassin's Creed Syndicate, for example, made Evie Frye a major playable lead alongside Jacob. Odyssey was distinctive because the player selected the protagonist's gender for the central campaign.

Kassandra is descended from Leonidas I and is tied to the Staff of Hermes Trismegistus, an Isu artifact that supports the game's modern-day framing story. Alexios is not an unrelated alternative character; he is the selectable counterpart to Kassandra, with the role changing according to the player's choice.