Which game in the Assassin's Creed series is set mainly in Rome and stars Ezio?

Assassin's Creed: Brotherhood is the game set mainly in Rome and starring Ezio Auditore. Ubisoft released it in 2010 as the third major game in the franchise and a direct continuation of Assassin's Creed II.

The story follows Ezio as he confronts the Borgia family, especially Cesare Borgia, and works to rebuild the Assassin Brotherhood. Rome serves as the game's principal open world, with districts that players can liberate and develop by disrupting Borgia control.

Brotherhood expanded the series with recruitable Assassins. Ezio can train allies and call them into missions, while the game also introduced a major multiplayer mode. Its modern-day sections continue Desmond Miles's storyline.

The setting is the key distinction among Ezio's three main games. Assassin's Creed II travels through several Italian cities, Brotherhood centers on Rome, and Revelations moves to Constantinople. The title therefore refers both to the organization Ezio rebuilds and to the game's broader themes of cooperation and succession.