Rome is the primary setting of Assassin’s Creed Brotherhood. The game continues Ezio Auditore’s story after Assassin’s Creed II and places him in the Papal States, where he works to weaken the Borgia family’s control over the city.
The open-world Rome includes major historical landmarks such as the Colosseum, the Pantheon, and Castel Sant’Angelo. Ezio also rebuilds parts of the city by investing in shops and services, linking economic development to progression through the story.
Brotherhood introduced a recruitment system that allowed Ezio to train other Assassins and call them into missions. Its multiplayer mode also expanded the series beyond the single-player campaign, although those competitive maps were separate from the main story’s Rome setting.
Florence and Venice are strongly associated with Assassin’s Creed II, while Constantinople is the central city in Assassin’s Creed: Revelations. Those connections make the games easy to mix up, but Brotherhood’s principal city is Rome.