The Boeing 767 was the first wide-body jet to use a two-crew flight deck.
Boeing designed the 767 with a flight deck for two pilots rather than the three-person crews common on earlier wide-body aircraft. The cockpit used electronic flight instruments and integrated systems to reduce workload while meeting regulatory and operational requirements.
The 767 first flew in 1981 and entered commercial service with United Airlines in 1982. Its development was closely linked to the narrow-body Boeing 757, and the two aircraft shared cockpit design features that allowed common pilot type-rating arrangements.
The Boeing 747 originally used a three-person flight deck, although later 747 versions adopted two-crew cockpits. The Boeing 777 also has a two-person flight deck, but it came later. This makes the 767 the specific answer when the question asks for Boeing’s first wide-body jet with that arrangement.