Which Assassin's Creed game takes place primarily in Constantinople?

Assassin's Creed Revelations takes place primarily in Constantinople.

The game follows Ezio Auditore in the early 16th century as he travels to Constantinople, the capital of the Ottoman Empire, to search for keys connected to Altaïr's legacy. The city is divided into districts reflecting its neighborhoods and political structure, and Ezio becomes involved with Ottoman Assassins and local power struggles.

Revelations is the fourth major game centered on Ezio and also returns to Altaïr through playable sequences set earlier in the timeline. This dual structure makes it a concluding chapter for both characters rather than a story focused solely on Constantinople.

The historical city is now commonly called Istanbul, but Constantinople is the name used for the game's setting and its period context. Rome, Florence, and Venice belong primarily to other Ezio-era titles.