Which Assassin's Creed game is the only main-series title set primarily during the American Revolution?

Assassin's Creed III is the main-series Assassin's Creed game set primarily during the American Revolution.

Released in 2012, the game follows Ratonhnhaké:ton, a Kanien'kehá:ka Assassin who uses the name Connor. Its historical setting includes the years surrounding the American Revolutionary War, with locations such as Boston, New York, and the American frontier.

Connor encounters historical figures including George Washington, Benjamin Franklin, and Charles Lee. The story explores the conflict between the Assassins and Templars while also portraying the political and military upheaval of the period.

Other games touch the same broad era. Assassin's Creed Rogue overlaps with the eighteenth-century colonial setting, and Liberation includes related locations and events, but Assassin's Creed III is the principal numbered entry centered on the American Revolution.