Which Assassin's Creed game is the first to feature Bayek of Siwa as its protagonist?

Assassin's Creed Origins is the first game to feature Bayek of Siwa as its protagonist.

Released in 2017, Origins follows Bayek, a Medjay from the Siwa Oasis, through Ptolemaic Egypt. His personal investigation develops into the origin story of the Hidden Ones, the organization that later becomes the Assassin Brotherhood.

Origins is set earlier than every preceding mainline game and explores locations including Alexandria, Memphis, Cyrene, and the Giza plateau. The title also significantly changed the series with role-playing systems, equipment levels, ability trees, and a larger emphasis on exploration. Bayek is not the protagonist of Odyssey, which follows a different hero in ancient Greece, or Valhalla, which centers on Eivor during the Viking Age.