Which Assassin's Creed game is set primarily in Rome and follows Ezio's leadership of the Brotherhood?

Assassin's Creed: Brotherhood is the Assassin's Creed game set primarily in Rome and centered on Ezio's leadership of the Brotherhood.

Released in 2010, Brotherhood continues Ezio Auditore's story after Assassin's Creed II. Ezio travels to Rome to oppose the powerful Borgia family and rebuild the city's Assassin network. The player can recruit and train Assassins, then call on them during missions.

Rome is presented as a large open-world city containing famous landmarks and districts controlled by enemy forces. A district's influence can be reduced by destroying Borgia towers, after which new shops and activities become available.

The title is sometimes confused with Revelations because both are Ezio games. Revelations takes Ezio to Constantinople and concludes his personal trilogy, whereas Brotherhood focuses on Rome and the expansion of the Assassin Brotherhood.