Which Assassin's Creed game is set primarily in Rome and focuses on Ezio's Brotherhood?

Assassin's Creed: Brotherhood is the Assassin's Creed game set primarily in Rome and focused on Ezio's Brotherhood.

Released in 2010, Brotherhood continues Ezio Auditore's story after Assassin's Creed II. Ezio works to weaken the Borgia family, whose power dominates Rome, while rebuilding the local Assassin organization.

The game lets players recruit and train new Assassins, then call on them during missions. This Brotherhood system is central to the title and reflects the game's broader theme of creating an organized resistance rather than acting alone.

Brotherhood is sometimes treated as a simple expansion of Assassin's Creed II, but it is a separate main release with its own campaign and multiplayer mode. Revelations follows later and moves much of Ezio's story to Constantinople.