Which Assassin's Creed game is set primarily in Renaissance Italy?

Assassin's Creed II is set primarily in Renaissance Italy.

Released in 2009, the game follows Ezio Auditore da Firenze across several Italian locations, including Florence, Monteriggioni, Venice, and Forlì. Its historical story begins in the late fifteenth century and places fictional Assassin activity alongside real figures and events from the Italian Renaissance.

The game expands substantially on the original Assassin's Creed with a larger world, economic systems, swimming, improved combat, and a broader range of missions. Ezio's relationship with figures such as Leonardo da Vinci gives the setting a strong connection to Renaissance culture and technology.

Assassin's Creed Revelations also features Ezio, but its principal setting is Constantinople, alongside sections connected to Altaïr. Unity is set in revolutionary Paris, while Assassin's Creed III focuses mainly on the American Revolution. Those neighboring settings explain why the games can be confused when the protagonist or time period is remembered more clearly than the location.