Which Assassin's Creed game is set primarily in Constantinople and features Ezio's final main adventure?

Assassin's Creed: Revelations is set primarily in Constantinople and features Ezio's final main adventure.

Released in 2011, Revelations follows an older Ezio as he travels to Constantinople in search of keys connected to Altaïr's legacy. The city is divided among competing powers, including the Byzantine Templars and the Ottoman forces.

The game alternates between Ezio's Renaissance-era story and memories of Altaïr Ibn-La'Ahad. This structure connects the two major historical protagonists and brings the original game's central mystery into Ezio's storyline.

Constantinople was the city's historical name during the game's period; it is now generally called Istanbul. That naming distinction can cause confusion, but “Constantinople” is the setting name used for the game's early 16th-century environment.