Which Assassin's Creed game is set primarily in ancient Egypt under Cleopatra?

Assassin's Creed Origins is set primarily in ancient Egypt under Cleopatra.

Released in 2017, Origins follows Bayek of Siwa during the final decades of the Ptolemaic Kingdom. Cleopatra VII is a major historical figure in the story, which also includes Julius Caesar and other people connected to the political struggles of the period.

The game depicts locations such as Siwa, Alexandria, Memphis, and Giza. Its story explores the formation of the Hidden Ones, the organization that later becomes associated with the Assassin Brotherhood.

Origins is set earlier than the other main historical games, but it was not the first game released in the franchise. Its role-playing systems, level progression, loot, and large Egyptian map also marked a major mechanical shift for the series.