Which Assassin's Creed game is set mainly in the Egyptian world of Cleopatra's reign?

Assassin's Creed Origins is set mainly in Egypt during Cleopatra's reign.

The game follows Bayek of Siwa and Aya during the first century BCE, when Ptolemaic Egypt is caught between internal politics and Roman intervention. Cleopatra, Julius Caesar, and Ptolemy XIII are among the historical figures connected to the story. The game uses this setting to explain the formation of the Hidden Ones.

Origins is not simply set in an earlier version of a later Assassin city: its world includes Alexandria, Memphis, Cyrene, the Siwa Oasis, and extensive desert regions. Cleopatra became queen in 51 BCE, and the game's events take place amid her struggle for power. The title refers to the fictional origins of the Assassin Brotherhood, while the franchise's first released game remains the 2007 Assassin's Creed.