Which Assassin's Creed game is set mainly during the American Revolution?

Assassin's Creed III is the series entry set mainly during the American Revolution.

Released in 2012, the game follows events in the Thirteen Colonies before, during, and after the Revolutionary War. Its historical storyline includes locations such as Boston, New York, and the American frontier. The protagonist is Ratonhnhaké:ton, a Kanien'kehá:ka man who adopts the name Connor for interaction with colonial society.

The game also features his father, Haytham Kenway, and uses their connected stories to present both Assassin and Templar viewpoints. Historical figures including George Washington and Benjamin Franklin appear in the narrative, alongside fictional conspiracies.

Assassin's Creed Unity is set in Paris during the French Revolution, while Syndicate takes place in Victorian London. Those games share the franchise's historical-fiction approach but belong to later periods and different protagonists.