Which Assassin's Creed game introduced the Egyptian city of Alexandria as a major setting?

Assassin's Creed Origins introduced Alexandria as a major setting.

Released in 2017, Assassin's Creed Origins is set in Ptolemaic Egypt during the first century BCE. Its open world includes Alexandria, Memphis, Cyrene, the Giza plateau, and extensive desert regions. Alexandria is especially important because it was a major cultural and political center during the period.

The protagonist, Bayek of Siwa, is a Medjay who investigates the forces behind a personal tragedy. His journey helps establish the historical origins of the Hidden Ones, the organization that later develops into the Assassin Brotherhood.

Origins is often confused with Odyssey because both games take place in the ancient Mediterranean. Odyssey is set primarily in Classical Greece and was released in 2018. Origins instead focuses on Egypt under Ptolemaic rule and marks a major shift toward role-playing systems, level progression, and a larger explorable world.