Which Assassin's Creed game follows Ezio Auditore's story in Renaissance Florence and Venice?

Assassin's Creed II follows Ezio Auditore's story through Renaissance Florence and Venice.

Released in 2009, Assassin's Creed II is set primarily in Italy during the late fifteenth century. Ezio begins as a young nobleman in Florence, but a family tragedy draws him into the conflict between the Assassins and the Templars. His search for justice gradually becomes a broader campaign against powerful conspirators.

The game features historical locations including Florence, Monteriggioni, San Gimignano, Forlì, Venice, and the Vatican area of Rome. Historical figures such as Leonardo da Vinci, Lorenzo de' Medici, and Rodrigo Borgia appear in the narrative, although the story is fictionalized.

Assassin's Creed II is the first game in the Ezio trilogy. Brotherhood continues his story in Rome, while Revelations follows him in Constantinople and also connects his arc with Altaïr's. The game's Italian Renaissance setting and expanded role-playing systems helped establish Ezio as one of the franchise's most recognizable characters.