Which Assassin's Creed game features the protagonist Bayek's wife, Aya, as a playable character?

Assassin's Creed Origins features Aya as a playable character.

Origins follows Bayek of Siwa and Aya during the first century BCE, when their personal story becomes connected to the formation of the Hidden Ones, the historical precursor to the Assassin Brotherhood. Aya is an important protagonist in her own right and is playable during several story sequences.

Aya's missions take her beyond Egypt, including to locations connected with the Roman world. Her relationship with Bayek is central to the game's emotional and political narrative, while their differing responsibilities show how the Hidden Ones begin to take shape.

The question can be confused with later games that also include multiple playable characters or temporary character changes. Odyssey centers on Kassandra or Alexios, and Valhalla centers on Eivor. Origins is the entry that combines Bayek's story with playable Aya sequences.