Which Assassin’s Creed game features the city of Masyaf as a major location?

The original Assassin’s Creed features Masyaf as a major location.

Masyaf is the headquarters of the Levantine Assassin Brotherhood during Altaïr Ibn-La’Ahad’s story. The fortress serves as Altaïr’s home base, where he receives missions, reports to Al Mualim, and returns after visiting other cities.

The game’s historical campaign is set during the Third Crusade, with major missions taking place in Jerusalem, Acre, and Damascus. Masyaf provides the organizational and narrative center connecting those missions.

Later Assassin’s Creed stories revisit or reference Masyaf, especially Assassin’s Creed Revelations, which follows Ezio’s search for Altaïr’s legacy. This can cause confusion, but the original game is the title that first establishes Masyaf as a principal setting.