Which Assassin's Creed game features the city of Florence during the Italian Renaissance?

Assassin's Creed II features Florence during the Italian Renaissance.

Florence is one of the major cities visited by Ezio Auditore da Firenze in Assassin's Creed II. The game presents the city as part of a broader journey through Renaissance Italy, alongside locations such as Venice, Monteriggioni, and Forlì.

Released in 2009, Assassin's Creed II follows Ezio as he becomes an Assassin and seeks answers about the conspiracy that destroyed his family. Its historical cast includes Leonardo da Vinci, Lorenzo de' Medici, and Caterina Sforza. Florence is sometimes mixed up with Rome, which is the principal setting of Assassin's Creed Brotherhood, the 2010 sequel. The two games both follow Ezio, but their urban centers and historical periods within his life are distinct.