What was the title of the 2010 Assassin's Creed game starring Ezio in Rome?

The 2010 Assassin's Creed game starring Ezio in Rome is Assassin's Creed: Brotherhood.

Brotherhood follows Ezio after the events of Assassin's Creed II and places him in Rome, where the Borgia family has concentrated political and military power. Ezio works to weaken their control, restore damaged districts, and create a network of fellow Assassins.

The game expanded the series with recruitable Brotherhood members, district renovation, and an economic system tied to rebuilding the city. It also continued the modern-day storyline involving Desmond Miles and the Assassin-Templar conflict.

Assassin's Creed II comes before Brotherhood and covers Ezio's rise in Renaissance Italy. Revelations follows Brotherhood and concludes Ezio's main story in Constantinople. Origins, by contrast, is a much earlier historical story centered on Bayek in Egypt.