Alfred Stieglitz first exhibited Georgia O'Keeffe's work at his gallery known as 291.
The gallery took its name from its address at 291 Fifth Avenue in New York City. Stieglitz opened it in 1905 as the Little Galleries of the Photo-Secession, and it became widely known simply as 291. It showed avant-garde photography alongside modern European and American art.
In 1916, Stieglitz displayed a group of O'Keeffe's charcoal abstractions there without her initial knowledge. He had received the drawings from her friend and fellow artist Anita Pollitzer. The exhibition brought O'Keeffe into the New York art world and began a professional and personal relationship with Stieglitz.
The gallery closed in 1917 because of financial difficulties. Stieglitz later operated other spaces, including the Intimate Gallery and An American Place, so 291 should not be confused with those later venues.