What movie matched animation with live action human characters?

The movie that matched animation with live-action human characters is Who Framed Roger Rabbit. Released in 1988 and directed by Robert Zemeckis, it placed animated cartoon characters and human actors together in the same scenes.

The film follows private detective Eddie Valiant, played by Bob Hoskins, as he investigates a murder accusation involving Roger Rabbit. Its fictional 1947 Hollywood includes a place called Toontown, where humans and animated “toons” coexist. The story was adapted from Gary K. Wolf's novel Who Censored Roger Rabbit?, though the movie significantly changed the book's characters and premise.

The production was technically demanding. Animators, supervised by Richard Williams, drew the cartoon characters to match live-action camera movements and performances. The film used cel animation and optical compositing rather than the modern digital effects pipeline. Disney and Steven Spielberg's Amblin Entertainment produced it, and several studios allowed famous cartoon characters—including Bugs Bunny and Donald Duck—to appear together. The movie's blend of noir mystery, comedy, and animation influenced later hybrid films.