What do the droid doctors cite as the reason Padme is dying at the end of Episode III?

The droid doctors cite Padmé Amidala’s loss of the will to live as the reason she is dying at the end of Episode III: Revenge of the Sith.

After Anakin Skywalker attacks Padmé on Mustafar, Obi-Wan brings her to a medical facility on Polis Massa. The medical droids report that she is medically healthy, yet she is rapidly weakening. They cannot identify a physical injury severe enough to explain her condition, so the diagnosis given in the film is that she has lost the will to live.

Padmé gives birth to twins, Luke and Leia, before dying. Her emotional collapse follows Anakin’s transformation into Darth Vader, his betrayal of the Jedi, and his attempt to kill her. The film presents those events as the dramatic context for her loss of hope, though it does not provide a detailed medical mechanism.

A common mix-up is answering “childbirth is killing her.” Childbirth occurs immediately before her death, but the droids explicitly say it is not the cause. Likewise, “she is mortally wounded” is not the stated diagnosis: the film says she is physically healthy. The answer is a famously debated plot point, but it is the canonical line spoken by the medical droid.