The surname of House M.D.’s diagnostician and main character, Gregory, is House. His full name is Dr. Gregory House, and the series title uses his surname.
House is a physician specializing in diagnostic medicine at Princeton-Plainsboro Teaching Hospital. He is known for solving cases that other doctors cannot explain, often by combining unusual hypotheses with extensive testing and a willingness to challenge standard assumptions.
The character’s surname also signals the show’s literary connection to Sherlock Holmes. House and Holmes share deductive methods, social isolation, drug dependence, and a close companion whose name echoes the Holmes canon: James Wilson parallels Dr. John Watson. The resemblance is an influence rather than a literal adaptation.
Because the program is usually called simply House, some viewers may treat “House” as a nickname or job-related label. It is his family name. Gregory is the character’s given name, while Dr. House is the standard professional form used by patients and colleagues.