What is the surname of House M.D. character Gregory House’s best friend, James?

The story behind the answer

Gregory House’s best friend James has the surname Wilson in House M.D.

James Wilson is a physician specializing in oncology at Princeton-Plainsboro Teaching Hospital. He and House have a friendship built on sharp differences: Wilson is generally empathetic and socially considerate, while House is famously abrasive and skeptical of convention.

Their relationship is one of the show’s main continuing stories. Wilson often acts as House’s emotional counterweight, but he is not merely a passive helper; the series gives him independent professional, romantic and family storylines.

The names Foreman, Chase and Taub belong to doctors who serve on House’s diagnostic teams at different points. They are therefore plausible answers for viewers remembering the hospital staff, but James House’s closest friend is James Wilson, played by Robert Sean Leonard.

Source: Wikipedia · fact-checked Oct. 2026

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