What is the name of the Isu artifact central to Assassin's Creed II's ending?

The Isu artifact central to Assassin's Creed II's ending is the Apple of Eden.

In Assassin's Creed lore, Apples of Eden are Pieces of Eden created by the Isu, an advanced civilization that existed before humanity's recorded history. They can influence human minds and are sought by both the Assassins and the Templars because of their potential power.

Assassin's Creed II follows Ezio Auditore's search for one of these Apples across Renaissance Italy. The artifact ultimately brings him to the Vatican, where he encounters the enigmatic figure known as Minerva. This ending links Ezio's historical story to the wider modern-day conflict involving Desmond Miles.

The franchise contains several different Pieces of Eden, including the Shroud, Staff, and Sword. They are not interchangeable: each has a distinct history and function. “Apple of Eden” refers to a category of spherical artifacts, rather than one unique object appearing only once.