What is the name of the first Assassin's Creed game to feature a fully playable female protagonist?

Assassin's Creed III: Liberation is the first Assassin's Creed game to feature a fully playable female protagonist.

Its protagonist is Aveline de Grandpré, a French-African Assassin active in eighteenth-century New Orleans and the surrounding Louisiana region. Players control Aveline throughout the campaign rather than encountering her only as a supporting character or in a limited sequence.

Liberation was originally released for the PlayStation Vita in 2012. It was later remastered and released for additional platforms. The game is sometimes confused with Assassin's Creed Syndicate because Syndicate features Evie Frye as a major playable character, but Liberation predates it. Aveline's story also connects thematically and historically with the events surrounding Assassin's Creed III.