What is the name of the first Assassin's Creed game centered on a female protagonist, Evie Frye?

Assassin's Creed Syndicate is the game centered on Evie Frye, alongside her twin brother Jacob.

Syndicate is set in London during the Industrial Revolution, beginning in 1868. Evie and Jacob Frye are Assassin twins who arrive in the city and work to weaken Templar control. Although both characters are playable, Evie receives a major storyline focused on stealth, investigation, and recovering a Piece of Eden. Jacob's missions more often emphasize direct combat and gang leadership.

The game is notable for making Evie the first female protagonist of a mainline Assassin's Creed game. Earlier titles featured playable female Assassins in other formats or roles, including Aveline de Grandpré in Assassin's Creed III: Liberation. That distinction explains why Liberation is a tempting but incorrect answer when the question specifies the mainline series.

Syndicate also introduced the grappling hook, carriage-based travel, and the Rooks gang system. Historical figures such as Charles Darwin, Charles Dickens, and Queen Victoria appear in its Victorian London setting.