Venice is the Assassin's Creed II city modeled on Renaissance Venice.
Ezio reaches Venice during the later part of Assassin's Creed II, where the game recreates recognizable features of the lagoon city, including canals, bridges, rooftops, and major landmarks. The city provides a striking contrast with Florence and Monteriggioni, which appear earlier in Ezio's journey.
Historically, Venice was a powerful maritime republic and a major center of trade, diplomacy, and artistic activity. The game draws on that identity by making waterways and dense urban architecture important parts of movement and mission design. Several story events also connect Ezio's investigation to the city's political and religious institutions.
Florence is a frequent mix-up because it is Ezio's home city and a major early location. Rome belongs primarily to Assassin's Creed: Brotherhood, while Constantinople is the main historical setting of Assassin's Creed: Revelations.