What is the name of the Assassin's Creed game set primarily in Renaissance Italy and starring Ezio Auditore?

Assassin's Creed II is the game set primarily in Renaissance Italy and starring Ezio Auditore.

Released in 2009, the sequel follows Ezio from his youth in Florence through his transformation into an Assassin. Its story travels across several Italian locations, including Florence, Monteriggioni, Venice, and Forlì, while connecting Ezio's personal conflict to a wider struggle with the Templars.

The game expanded substantially on the original with economic upgrades, more varied weapons, improved social systems, and a longer character arc. Historical figures such as Leonardo da Vinci, Niccolò Machiavelli, and Caterina Sforza appear in the story.

Brotherhood continues Ezio's life but is primarily centered on Rome, while Revelations brings him to Constantinople. Origins instead follows Bayek in ancient Egypt. Those neighboring titles can cause confusion, but Assassin's Creed II is the Renaissance Italy entry itself.