Pokémon Pokopia is set in a post-apocalyptic version of the Kanto region.
The game presents Kanto in an unusual state: humans have left, the environment has become difficult to inhabit, and Pokémon habitats must be restored. This setting reuses a familiar Pokémon region while giving it a new purpose centered on rebuilding rather than collecting badges.
Early in the story, Ditto finds its trainer’s old Pokédex and assumes a form based on that trainer. It then meets Professor Tangrowth, who is investigating the damaged environment and the mystery of the humans’ disappearance.
Kanto is easy to confuse with other regions because Pokopia includes Pokémon from Generations I through IX. The setting is still Kanto, however; the wide selection of Pokémon reflects the game’s roster, not a change to the region where the story takes place.