The Isu created the Pieces of Eden in the fictional mythology of Assassin's Creed.
The Isu are an advanced precursor civilization that existed before recorded human history in the series' setting. They created powerful artifacts collectively known as Pieces of Eden, including the Apples of Eden, the Staff of Hermes, and the Sword of Eden. These objects can influence human minds or produce other extraordinary effects.
Older games often referred to the Isu as the First Civilization, and some characters use related terms such as the Precursors. Those descriptions identify the same broad civilization, but “the Isu” is the canonical name most directly used in later series lore. The artifacts are not ordinary historical objects; they are fictional elements woven into otherwise recognizable historical periods.
The Isu also created humans through genetic engineering and appear in the modern-day storyline through surviving recordings, simulations, and memories. Their civilization was devastated by a global catastrophe before humanity became dominant.