In Blade Runner, the replicant who kills his creator is Roy Batty.
Roy Batty is the leader of a group of escaped Nexus-6 replicants who return to Earth in 2019. The replicants are bioengineered humanoids produced for dangerous off-world labor, military service, and other roles. Batty is a combat model, and his urgent goal is to find a way to extend the four-year lifespan imposed on Nexus-6 models.
Through J. F. Sebastian, Batty reaches Eldon Tyrell, founder of the Tyrell Corporation and the man he regards as his creator. Tyrell explains that Batty’s life cannot be extended. Batty then kills him by crushing his eyes and skull; he also kills Sebastian afterward. This makes Roy different from the other listed characters: Zhora, Pris, and Leon are fellow replicants, but they do not kill Tyrell.
The film gives Batty a more complex ending than a conventional villain receives. During his final pursuit of Deckard, Batty saves the blade runner from falling to his death. He then delivers the “tears in rain” speech before dying as his engineered lifespan expires.