The main campaign of Assassin's Creed Syndicate is set in London in 1868.
The game places twins Jacob and Evie Frye in Victorian London during the Industrial Revolution. They arrive from Crawley and build an organization to challenge Templar control over the city. The campaign travels through districts such as Westminster, the City of London, Southwark, and Lambeth.
The year 1868 is important because it places the story after the major phase of Britain's industrial expansion but before the end of the Victorian era. The game uses period technologies and social conditions, including railways, factories, organized gangs, and large differences in wealth.
Syndicate is sometimes confused with Assassin's Creed Unity because both games feature European cities and dense urban maps. Unity is set in revolutionary Paris in the late eighteenth century, whereas Syndicate uses London in the nineteenth century. Historical figures including Charles Dickens, Karl Marx, and Queen Victoria appear in the game, alongside its fictional Assassin protagonists.