In Assassin's Creed Syndicate, the player controls Jacob Frye first in the opening sequence.
Jacob and his twin sister Evie are the central playable Assassins in Syndicate. The pair leave Crawley and travel to London in 1868, where they begin dismantling Templar control during the Industrial Revolution.
Jacob is controlled first during the opening train sequence and the initial London missions. Evie becomes playable shortly afterward, and later activities allow the player to switch between the twins. Their contrasting strengths shape the campaign: Jacob favors direct combat and gang leadership, while Evie specializes more heavily in stealth and investigation.
Henry Green, an Assassin ally, helps the twins in London but is not one of the playable siblings. Maxwell Roth is a criminal leader and antagonist. The game's dual-protagonist structure was a major distinction from earlier entries centered on one primary historical character.