In Assassin's Creed Syndicate, Evie Frye is the playable female Assassin twin.
Evie and her twin brother Jacob are the central protagonists of Syndicate. The game allows players to control both characters, but Evie is the sister who specializes more strongly in stealth and searching for the Pieces of Eden. Jacob generally focuses on direct combat and gang leadership.
Their story takes place in Victorian London in 1868. The twins arrive in the city, build the Rooks gang, and oppose the Templars’ control over London’s criminal and industrial networks. The campaign divides some missions by protagonist while allowing both characters to be upgraded.
Evie Frye is distinct from Lydia Frye, a later descendant who appears in the World War I sequence. Jacob is also playable, so the question is specifically identifying the female twin rather than asking for the game’s sole protagonist.