In Assassin's Creed Syndicate, Jacob and Evie Frye work to free London. The game is set in Victorian London in 1868, during the Industrial Revolution, and follows the twin Assassins as they challenge Templar control of the city.
Jacob establishes the Rooks, a street gang that helps reclaim districts from the rival Blighters. Evie focuses more heavily on locating an important Piece of Eden and confronting the Templar Grand Master Crawford Starrick. Their different approaches are central to the game's structure.
Paris is the setting of Assassin's Creed Unity, while Manchester and Birmingham are English cities but are not the principal open-world setting of Syndicate. The game recreates London landmarks and neighborhoods, including Westminster, the City of London, Southwark, and the Thames.